According to the textbook by the Life Extension Foundation entitled “Disease Prevention and Treatment ” 5t Edition on page 608, pregnenolone -the “mother hormone”- is synthesized from cholesterol in the adrenal gland, and then through DHEA and the intermediate hormone androstenediol it cascades to produce both the male hormone testosterone and the female hormones collectively called the estrogens. According to the authors the estrogens are a mixture of 3 separate female sex hormones: Estrone,Estradiol, and Estriol in different proportions and with different functions
It occurred to me that maybe the difficulty for some individuals to determine their own gender and sexual behaviour may be the result of shifts in the concentrations of these different hormones.I recall in my own medical practice that I diagnosed a case of Kleinfelter’s syndrome based on the presence of an extra X (sex) chromosome-which incidentally was made in my own private Western Cytogenetic Laboratory.
Tag: pregnenolone
Cholesterol controversy
With the knowledge of the role that cholesterol plays in the biosynthesis of the sex hormones precursors (pregnenolone and DHEA), the integrity of the myelin sheath of nerve fibres and possible role in multiple sclerosis, as well as a natural nutrient antioxidant and/or free radical scavenger it was gratifying to hear and to see on TV that the dietary restriction of cholesterol has been waved.
In my previous blogs I have for years advised against the use of cholesterol lowering drugs,not only for these functions but also for the studies which found a relationship of cardiomyopathy associated with certain statin drugs, especially in women.
I wonder how soon and if doctors will stop prescribing statin and other cholesterol lowering drugs-