Some new biomarkers of aging

I just browsed Ward Dean’s book entitled Biological aging measurement If the reader turns to Chapter 8 beginning on page 72  you can see  data from the University of South Wales on 6 parameters- beginning with BUN (blood urea nitrogen), FEV1,(forced vital capacity ),SBP (systolic blood pressure), AP (alkaline phosphatase), ESR (Erythrocyte sedimentation rate ), and C Cholesterol in mg/100 ml. They compare tlevalues from people of different biological ages.

Although it is somewhat difficult to compare the values, it appear that the values are different from differant age groups . It may be that when a doctor finds an elevated value he should be aware that they may just indicate that the  natural aging process of that individual  is more activate than others for that chronological age group- just like you see some people who have more facial wrinkles than others off the same age group.

Coenzyme Q 10 -Another biomarker of the aging process

For details of this finding the reader should consult the latest publication (Oct 2018) of there Life extension magazine where they discuss this natural product known scientifically as ubiquinone.   As with all of their products their disclaimer would also be read.Here it is :”These statements have not been evaluated by the Food and D Administration. This product is not intended to diagnose, treat, cure, or prevent any disease ”

Briefly as we age – like with the natural steroid hormone DHEA the level of this product in our blood falls markedly as we  age with levels dropping  to less than 20 % of that found during our adolescence period. They also recommend using only ubiquinol and not ubiquinone and that one should use the a natural derivative  product to increase absorption.For more  details on usage and dosage supplementation  read their instructions including of course their disclaimer.

Gerontology basics:Aging process is basically a disease.

Will try to insert a table outlining 7 ways to slow the aging process.  Gerontologists search for biomarkers of aging by comparing clinical and laboratory values for different ages of the biological life cycle. For example find that the level of the most common hormone in the body , viz DHEA drops from a value of over 3000 nannograms /ml in the 30-40 age group to less tan 1000 ngms in the elderly.

Gerntologists rationalize  that by restoring this hormone  value to that found in the younger age group should also restore the Physical/physiological and other properties to those present in the younger age group especially  including  the other hormones of the steroid cascade  (testosterone,  estrogens, etc. ) to those in our youth so that  the individual now feels  like they they did when they were in that 20-30 year period!

This table shows other areas were this reversal of aging could occur. 

Note since I have problems in dropping this table in this post I will save the post as a draft and not publish it.

Mitochondial vs Chromosomal DNA

Comparative DNA analysis is a very popular procedure in including and/or excluding individuals from a crime scene. However  since every person’s mitochondrial DNA is  of maternal origin, it is also easy with mitochondrial DNA  to prove that all her children- both the males and females   are hers.-  thats because the mitochondria are only found in cytoplasm and  the sperm which fertilizes an oocyte (egg cell)  does not have  any cytoplasm.  At least that  the theory.  It would be easy to prove this with cellular autoradiography using  tritiated thymidine providing such experiments met the code of ethics, probably not, then maybe our cousins – the chimpanzes wouldn’t, mind.

Hiring of advisors for professional sports.

For years I have be3en fascinated by the pharmacological properties of hydergine and have used it when I was in practice for mild forms of Alzheimer’s. Indeed several of my blogs as well as my posts have suggested that many of the functions of this drug suggest it may be useful in protecting against possible concussions following head injuries of athletes in contact  sports like hockey, football and soccer. I advise the readers to review these publications in my blog website. Additional coaches are sometimes recruited even of the opposite sex- in an effort to win games. They should also be recruting personnel to possibly prevent and/or reduce the incidence of such encephalopathy .  In the case of cardiac arrests, or drowning we immediately perform CPR  but in the case of head injuries we waste valuable time asking the victim if he knows were he is or what day it is, or the name of the prime minister  of Canada or the president of United States.. I have suggested in my earlier bogs that we should be evaluating  such athletes with head injuries either  parental forms of hydergine  or even prophylactally.

Possible Cervical spinal stenosis

I have a habit of sitting up in bed in the evening watching TV with a pillow propping up my neck before I decide to go to bed. At times I feel that my neck is often forwardly  flexed. Before I decide to “call it a day ” I place my pillow in its natural position and then lie supine on my back as I find lying on either  lateral position on either hip position is somewhat discomforting. I sometimes find when I get up during the night for going to the washroom I  get a numbness in both my forearms- feeling of “pins and needles” and wonder whether this is the result of sudden release of the nerve roots. Or maybe I also have symptoms of cervical spinal stenosis.  As a footnote: x-rays of my spine at all levels show considerable wedging of the vertebrae-especially in the thoracic region  

Possible lumbar spinal stenosis

My complaints of pain in left hip with numbness in buttocks and anterior aspect of left thigh with symptoms worsen standing and relieved by sitting, suggest a possible diagnosis of possible lumbar spinal stenosis at the level of L3 . Since the innervationof the left hip comes from the L3 nerve root. It is also possible that the pain is referred pain from the L3 nerve root – not unlike pain in the right shoulder from referred paid coming from C3 nerve root – the same nerve which innervated the diaphragm. For this scenario one needs inflammation of the diaphragm from an infected gall bladder; Damage of cardiac muscle T1-2 causing numbnessalonf medial aspect of forearm; careful history of appendicitis will reveal the numbness began in the paraumbilical region (innervation of appendix). The subsequent tenderness and especially rebound tenderness  in the RLQ of the abdomen id due to local inflammation of abdominal muscles in that area of the abdomen. I greatly appreciate having taking several week long courses in Orthopaedic medicine by Stephanie Suders – private physiotherapist of the famous Sir James Cyriax.While working as a Medical advisor for the Workers Compensation Board of Manitoba in the 1980’s I was appalled at the quality of the medical reports we received from the attending physician of the claimant so much so that the board on my advise sponsored a 3 day weekend workshop outlining the fundamentals of Orthopaedic Medicine- viz the examination and non surgical treatment of musculoskeletal problems.  Dr. Don Fraser and his therapist presented this course.

Crisis in Canadian health care

In Canada most people have to wait a year or even  longer to have hip or knee surgery. The waiting time for this  procedure seems to have reached epidemic proportions.This reminds me of the polio pandemic of the 1940-50’s . The voluntary organization which was raising funds for this pandemic had 2 choices- “…It could have invested their resources into perfecting better iron lungs… Instead of iron lungs , the Foundation invested heavily in basic research on the conquest of polio. It was certainly the wiser decision” -a quote from Roy Walford textbook entitled  Maximum Life Span page 7.. Maybe our governments should follow this pattern for this disease. They may also wish to consider this same strategy for cataracts which  now has long waiting list  for a year or longer.

Politics priority-pipeline assistance vs Churchill railroad

If recent negotiation with the BC government fails before end of May 2018,  our federal  government is willing to  help financially  the cost of  this interprovincial pipeline from Alberta to the Vancouver port, but not for the repair on the washout railway line to Churchhill- a problem  unresolved for over 2 years and which has resulted in the cost of living for residents of Churchill.  Where are our government  priorities?