transgender vs cis(gender)

Cis(gender)- is defined as the sex you are assigned at birth, while transgender is an umbrella term for people whose gender identity differs from the sex they are assigned at birth.

Recently I have been working on various keynote presentations on the paradigm shift for gerontology, specifically on anti-aging.  To ‘add life to your years and years to your life’,  it seems gerontologists have shifted from pursing life extension strategies to anti-aging.

In that regard I have searched for more information on the biological markers for aging. One of the tests I have found relates to the significant loss of hormone levels, specifically DHEA. According to Roy Walford in his textbook (The 120 year diet ) table 2.2 in males DHEA  declines from 3400 ng./ml of plasma in the 20-30 age group to less than 900 ng/ml by age 60. Corresponding figures for females are 2200 to 800 .

The Fifth edition (2013) of Disease Prevention and Treatment  published by Life Extension Foundation on p. 608 details how DHEA is converted to Androstenediol an intermediate hormone which can then produce either and/or  both– the male and female sex hormones, viz. testosterone and the 3 major estrogens (estrone,, estradiol and estriol).  The hormonal cascade also shows that the enzyme aromatase can convert testosterone to the female sex hormones.

I wonder if an imbalance of this hormonal cascade can produce the increase in transgenders we are witnessing. Maybe by altering these conversions we could preventive the transgender phenomenon.



Sex hormonal imbalance possible role in sexual orientation

According to the textbook by the Life Extension Foundation entitled “Disease Prevention and Treatment ” 5t Edition on page 608, pregnenolone -the “mother hormone”- is synthesized from cholesterol in the adrenal gland, and then through DHEA and the intermediate hormone androstenediol it cascades to produce both the male hormone testosterone and the female hormones collectively called the estrogens. According to the authors the estrogens are a mixture of 3 separate female sex hormones: Estrone,Estradiol, and Estriol in different proportions and with different functions
It occurred to me that maybe the difficulty for some individuals to determine their own gender and sexual behaviour may be the result of shifts in the concentrations of these different hormones.I recall in my own medical practice that I diagnosed a case of Kleinfelter’s syndrome based on the presence of an extra X (sex) chromosome-which incidentally was made in my own private Western Cytogenetic Laboratory.